Photodynamic Therapy for Choroidal Metastasis.
Devon H Ghodasra1, Hakan Demirci1
1Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.
American Journal of Ophthalmology
|October 4, 2015
Summary
Photodynamic therapy (PDT) effectively managed choroidal metastasis in selected patients, stabilizing or improving vision in most cases. PDT demonstrated significant tumor flattening and resolution of subretinal fluid with no complications.
Area of Science:
- Ophthalmology
- Oncology
- Medical Imaging
Background:
- Choroidal metastasis presents a significant challenge in ocular oncology.
- Effective treatment options for choroidal metastasis are crucial for preserving visual function.
Purpose of the Study:
- To evaluate the efficacy of photodynamic therapy (PDT) in managing choroidal metastasis.
- To assess visual acuity, tumor characteristics, and associated features following PDT.
Main Methods:
- Retrospective analysis of patients with choroidal metastasis treated with PDT.
- PDT administered using verteporfin (6 mg/m²) and a 689 nm diode laser.
- Key metrics included visual acuity, tumor dimensions (ultrasound, EDI-OCT), and subretinal fluid.
Main Results:
- 69% of eyes maintained or improved visual acuity after a mean 12-month follow-up.
- 81% of tumors became flat, with significant reductions in thickness measured by ultrasound and EDI-OCT.
- 86% of tumors showed complete resolution of subretinal fluid; no PDT-related complications occurred.
Conclusions:
- Photodynamic therapy is a potentially effective treatment for choroidal metastasis in select patients.
- PDT offers a favorable safety profile and can lead to significant tumor regression and visual stabilization.
