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Related Experiment Video

Updated: Apr 1, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

Common food allergens and their IgE-binding epitopes.

Hiroaki Matsuo¹, Tomoharu Yokooji², Takanori Taogoshi¹

¹Department of Pharmaceutical Services, Hiroshima University Hospital, Hiroshima, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology

|October 5, 2015

Summary

Food allergies are immune responses to specific foods. Identifying allergen components and IgE epitopes aids in diagnosing food allergies, predicting severity, and developing tolerance.

Keywords:

Allergen Diagnosis Epitope Food allergy Immunoglobulin E

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Area of Science:

Immunology
Allergology
Molecular Biology

Background:

Food allergy is an adverse immune response to food, with chicken egg, cow's milk, wheat, shellfish, fruit, and buckwheat causing 75% of cases in Japan.
Allergen-specific immunoglobulin E (IgE) antibodies are crucial in food allergy development.
Molecular biology advancements facilitate food allergen analysis.

Purpose of the Study:

To review current knowledge on food allergens and IgE epitopes.
To highlight the role of IgE antibodies in food allergy diagnosis and management.

Main Methods:

Review of scientific literature on food allergens and IgE epitopes.
Analysis of molecular structures and IgE-binding epitopes of common food allergens.

Main Results:

Identification of numerous food allergens, their structures, and IgE-binding epitopes.
Demonstration that IgE antibodies to specific allergen components/epitopes indicate allergy, severity, and tolerance potential.

Conclusions:

IgE epitope mapping is valuable for diagnosing food allergies.
Understanding allergen components and IgE epitopes aids in predicting clinical outcomes and tolerance development.