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Clonazepam treatment of five lithium-refractory patients with bipolar disorder
T A Aronson1, S Shukla, J Hirschowitz
1Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8101.
The American Journal of Psychiatry
|January 1, 1989
Abstract:
The authors describe the first five patients enrolled in an open clinical trial of clonazepam as a maintenance treatment in lithium-refractory bipolar disorder. All patients relapsed quickly after taking clonazepam (one within 2 weeks and four within 10-15 weeks), and the study was prematurely terminated. The results cast doubt over the usefulness of clonazepam as a prophylaxis in lithium-resistant bipolar patients who have histories of psychotic mania or delusional depression.