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Verbal memory and menopause.

Pauline M Maki1

  • 1University of Illinois at Chicago, College of Medicine, Neuropsychiatric Institute (MC913), 912 South Wood Street, Chicago, Illinois 60612, USA.

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|October 5, 2015
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Summary
This summary is machine-generated.

Midlife women experience memory changes during menopause. Hormone therapy may improve memory and vasomotor symptoms, suggesting a link between these menopausal transition effects.

Keywords:
Hormone therapyHot flushHysterectomyMemoryMenopauseVasomotor symptoms

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Women's Health

Background:

  • Midlife women often report memory difficulties during the menopausal transition.
  • Studies confirm correlations between subjective memory complaints and objective memory task performance.
  • Longitudinal data show verbal memory may decline during this transition and rebound postmenopause.

Purpose of the Study:

  • To investigate the role of estradiol in memory during the menopausal transition.
  • To explore the relationship between objectively measured vasomotor symptoms (VMS) and memory performance.
  • To address the lack of clinical trials on hormone therapy's (HT) effects on both memory and VMS in women needing treatment.

Main Methods:

  • Review of longitudinal and clinical studies on memory changes during menopause.
  • Examination of hormone withdrawal and add-back hormone therapy (HT) effects on memory.
  • Analysis of emerging evidence linking objectively measured VMS to memory and brain activity.

Main Results:

  • Estradiol plays a critical role in memory function.
  • Memory problems during transition persist even after controlling for menopausal symptoms.
  • Objectively measured VMS, not self-reported, correlate with memory performance and brain changes.

Conclusions:

  • Memory complaints during menopause are common and may be temporary.
  • Estradiol is crucial for memory, and HT may benefit memory.
  • Further research is needed on HT's impact on both memory and objectively measured VMS.