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Updated: Apr 1, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Histopathological features of sinonasal inverted papillomas in chinese patients
Li Zhao1,2, Chun Wei Li3, Peng Jin1,2
1Department of Otolaryngology , The Second Affiliated Hospital, Shandong University, Shandong, China.
Objectives/Hypothesis:
Nasal inverted papilloma (IP) is a benign tumor with high recurrence rates. Evidence of inflammation has been reported in IP in Caucasian studies. This study aimed to investigate the histopathological patterns and their associations with clinical characteristics in Chinese patients with IP.
Study Design:
Basic science study.
Methods:
IP tissues were obtained from 50 Chinese patients with unilateral IPs. Biopsies of inferior turbinate mucosa from 17 healthy subjects were used as controls. The histological patterns and severity of epithelial remodeling and inflammatory cell infiltration were evaluated and analyzed for associations with clinical characteristics.
Results:
Thirty-one percent of IP specimens were classified as grade I (mild remodeling) and 49% as grade II (moderate and severe remodeling). Concomitant inflammatory nasal polyps were found in 14 patients (28%). Recurrent IP was strongly associated with grade II (odds ratio: 5.81, 95% confidence interval: 1.34-25.18). Except CD4(+) T cells, quantities of neutrophils, macrophages, eosinophils, CD8(+) T cells, and FoxP3(+) T-reg cells were significantly elevated in IP. Of these, neutrophils were the predominant cell type in IP.
Conclusions:
Inflammation may have potential roles in IPs and the higher grade of epithelial remodeling was associated with the recurrence of IPs.
Level Of Evidence:
NA.
