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Left Ventricular Hypertrophy Phenotype in Childhood-Onset Essential Hypertension

Monesha Gupta-Malhotra1,2, Syed Shahrukh Hashmi3, Tim Poffenbarger2

  • 1Division of Pediatric Cardiology, Department of Pediatrics, Children's Memorial Hermann Hospital, The University of Texas Health Science Center, Houston, TX.

Journal of Clinical Hypertension (Greenwich, Conn.)
|October 6, 2015
PubMed

Insights

Obesity and high systolic blood pressure (BP) are key risk factors for left ventricular hypertrophy (LVH) in children with primary hypertension. Managing weight and BP is crucial for reversing LVH.

Area of Science:

  • Pediatric Cardiology
  • Hypertension Research
  • Cardiovascular Health

Background:

  • Left ventricular hypertrophy (LVH) is a significant concern in pediatric primary hypertension.
  • Identifying risk factors is crucial for early intervention and management in children.

Purpose of the Study:

  • To determine the independent risk factors for left ventricular hypertrophy (LVH) in untreated children with primary hypertension.
  • To investigate the association between obesity, systolic blood pressure (BP), and LVH in this pediatric population.

Main Methods:

  • Prospective study involving 89 children with untreated primary hypertension.
  • Hypertension confirmed via 24-hour ambulatory blood pressure monitoring.
  • Left ventricular mass (LVM) index calculated and LVH defined using the 95th percentile.

Main Results:

  • Both obesity and systolic BP were independently associated with LVH.
  • Obesity demonstrated a significant, nearly nine-fold increased risk of LVH.
  • The relationship between systolic BP and LVH was more pronounced in nonobese children.

Conclusions:

  • Obesity and elevated systolic BP are critical risk factors for LVH in pediatric primary hypertension.
  • Weight management and BP control are essential therapeutic strategies for reversing LVH in affected children.

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