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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Correlation between Microvascular Density and Matrix Metalloproteinase 11 Expression in Prostate Cancer Tissues: a

Nongnuch Kanharat1, Panya Tuamsuk

  • 1College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, Thailand

Asian Pacific Journal of Cancer Prevention : APJCP
|October 6, 2015
PubMed
Abstract

Insights

Matrix metalloproteinase 11 (MMP11) expression in prostate cancer correlates with microvascular density (MVD), suggesting MMP11 may promote tumor angiogenesis by altering the stromal microenvironment.

Area of Science:

  • Oncology
  • Cancer Biology
  • Pathology

Background:

  • Prostate cancer poses a significant public health challenge.
  • Microvascular density (MVD) serves as a prognostic indicator in various solid tumors.
  • Matrix metalloproteinase 11 (MMP11) is implicated in angiogenesis and tumor progression.

Purpose of the Study:

  • To examine the association between MVD and MMP11 expression in prostatic adenocarcinoma.
  • To elucidate the role of MMP11 in prostate cancer angiogenesis.

Main Methods:

  • Immunohistochemical analysis of MMP11 and MVD in 50 prostatic adenocarcinoma specimens.
  • Quantitative assessment of microvascular density (MVD) per square millimeter.

Main Results:

  • MMP11 expression was predominantly observed in stromal cells, with minimal presence in epithelial cells.
  • Mean MVD was 36/mm², significantly correlating with bone metastases.
  • A significant positive correlation was found between MVD and MMP11 expression (r=0.29, p=0.044).

Conclusions:

  • MMP11 may influence the prostate cancer stromal microenvironment.
  • MMP11 could potentially stimulate tumor angiogenesis in prostate cancer.

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