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Updated: Apr 1, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles
S K Misra1, X Wang, I Srivastava
1Department of Bioengineering, Beckman Institute for Advanced Science and Technology, Materials Science and Engineering, Carle Foundation Hospital, University of Illinois at Urbana-Champaign, and Carle Foundation Hospital, 502 N. Busey, Urbana, USA. dipanjan@illinois.edu.
Abstract:
We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.
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