Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based
Jordan Atchison1, Sukanta Kamila1, Conor McEwan1
1Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
Abstract:
A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.
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