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Published on: May 12, 2023
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Dual fluorescent deoxyguanosine mimics for FRET detection of G-quadruplex folding
Darian J M Blanchard1, Thomas Z Cservenyi, Richard A Manderville
1Departments of Chemistry & Toxicology, University of Guelph, Guelph, Ontario, Canada N1G 2w1. rmanderv@uoguelph.ca.
Abstract:
Replacement of deoxyguanosine (dG) nucleobases within G-tetrads of G-quadruplex folding oligonucleotides with donor (D)/acceptor (A) fluorescent 8aryldG residues provides diagnostic FRET signalling for G-quadruplex detection.

