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Melatonin and Ischemic Stroke: Mechanistic Roles and Action
Syed Suhail Andrabi1, Suhel Parvez1, Heena Tabassum2
1Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India.
Advances in Pharmacological Sciences
|October 6, 2015
Summary
Stroke causes significant disability worldwide, with ischemic stroke being the most common. This review explores stroke mechanisms and melatonin
Area of Science:
- Neuroscience
- Neurology
- Pharmacology
Background:
- Stroke is a leading cause of neurological disability and mortality globally.
- Ischemic stroke, characterized by disrupted blood flow, is the most prevalent type.
- Pathological cascades in stroke include oxidative stress, excitotoxicity, and mitochondrial dysfunction.
Purpose of the Study:
- To review the causes and consequences of stroke.
- To elucidate the neuroprotective role of melatonin in ischemic stroke.
Main Methods:
- Literature review of stroke pathophysiology.
- Analysis of melatonin's mechanisms of action in neurological injury models.
Main Results:
- Melatonin exhibits antioxidative, antiapoptotic, and anti-inflammatory properties.
- These properties suggest a potential therapeutic role for melatonin in mitigating stroke-induced brain damage.
Conclusions:
- Melatonin demonstrates significant neuroprotective potential against ischemic stroke.
- Further research into melatonin as a therapeutic agent for stroke is warranted.
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