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Blood flow in the normal human retina.

G T Feke1, H Tagawa, D M Deupree

  • 1Eye Research Institute, Retina Foundation, Boston, Massachusetts 02114.

Investigative Ophthalmology & Visual Science
|January 1, 1989
PubMed
Summary

This study measured human retinal blood flow using laser Doppler, finding flow increases with vessel diameter, consistent with Poiseuille flow. Total retinal blood flow averaged 80 microliters/min, with higher flow to the temporal retina.

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Area of Science:

  • Ophthalmology
  • Physiology
  • Biomedical Engineering

Background:

  • Understanding retinal blood flow is crucial for diagnosing and managing ocular diseases.
  • Previous studies have provided estimates, but precise in vivo measurements in humans are limited.

Purpose of the Study:

  • To quantify blood flow rate in major retinal vessels of healthy human eyes.
  • To determine the relationship between blood flow rate and vessel diameter in retinal arteries and veins.
  • To calculate the total retinal blood flow and compare it to non-human primates.

Main Methods:

  • Laser Doppler velocimetry was employed to measure blood flow in 41 major retinal vessels across ten healthy subjects.
  • The relationship between blood flow rate (F) and vessel diameter (D) was analyzed.

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  • Total retinal blood flow was calculated by integrating measurements from individual vessels.

    • Main Results:

    • Blood flow rate (F) increased with vessel diameter (D) to the power of approximately 4.1, supporting Poiseuille flow principles.
    • The mean total retinal blood flow was determined to be 80 ± 12 microliters/min.
    • Retinal blood flow per unit mass aligned with values reported for macaque monkeys, with significantly higher flow to the temporal retina compared to the nasal side.

    Conclusions:

    • Laser Doppler velocimetry provides a reliable method for assessing human retinal hemodynamics.
    • The findings confirm Poiseuille flow characteristics in retinal vasculature and establish normative values for total retinal blood flow.
    • Significant regional variations in retinal blood supply exist, with implications for understanding localized retinal function and disease.