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Serum ferritin predicted prognosis in patients with locally advanced pancreatic cancer
Si-Liang Wang1, Shuo Cao1, Rong Wu1
1Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, Shenyang 110004, China.
Aim:
The present study evaluated the value of serum ferritin (SF) level for the prognosis of patients with locally advanced pancreatic cancer (LAPC).
Patients & Methods:
A total of 79 patients with LAPC treated by chemoradiotherapy were reviewed retrospectively. Pretreatment and post-treatment levels of SF were obtained.
Results:
Median progression-free survival (PFS) was 11.8 months; median overall survival was 18.3 months. A total of 36 patients with elevated SF level showed significantly worse overall survival and PFS than patients with low SF level (p = 0.002 and p = 0.004, respectively). In total, 17 patients showed normal SF level after chemoradiotherapy, and their median PFS was 3.2 months longer than that of patients whose SF levels were not restored after chemoradiotherapy.
Conclusion:
SF may serve as a valuable tool to assess prognosis and monitor chemoradiotherapy response in patients with LAPC.
