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Visceral Pain and Psychiatric Disorders
Modern Trends in Pharmacopsychiatry
|October 6, 2015
Summary
Visceral pain and psychiatric disorders like depression and anxiety frequently occur together, worsening patient quality of life. Research explores the overlapping brain-gut-microbiome axis in these conditions.
Area of Science:
- Neuroscience
- Gastroenterology
- Psychiatry
Background:
- High comorbidity between visceral pain and psychiatric disorders (depression, anxiety) significantly impacts quality of life.
- Overlapping pathophysiology between visceral pain and stress-related disorders is suggested but not fully understood.
- The relationship between psychiatric conditions and visceral hypersensitivity (bidirectional) remains unclear.
Purpose of the Study:
- To provide an overview of comorbid visceral pain and psychiatric disorders.
- To present evidence for potential overlapping pathophysiological mechanisms.
- To discuss preclinical models of these comorbid conditions.
Main Methods:
- Literature review and synthesis of existing research.
- Examination of the brain-gut-microbiome axis in relation to comorbid disorders.
- Discussion of preclinical models.
Main Results:
- The brain-gut-microbiome axis is implicated in both visceral hypersensitivity and psychiatric disorders.
- Alterations in this axis may represent a common pathophysiological link.
- Preclinical models offer insights into shared mechanisms.
Conclusions:
- The brain-gut-microbiome axis is a key area for understanding the comorbidity of visceral pain and psychiatric disorders.
- Further research is needed to clarify the precise mechanisms and causal relationships.
- Targeting this axis may offer novel therapeutic strategies.
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