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Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children: A randomized
Tao Huang1, Kristian Traberg Larsen1, Niels Christian Møller1
1Center of Research in Childhood Health (RICH), Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Insights
A 6-week camp intervention effectively reduced C-reactive protein (CRP) and leptin in children, but these effects were not sustained long-term. Changes in body fat mass mediated the impact on leptin levels.
Area of Science:
- Pediatric Health
- Metabolic Research
- Inflammation Studies
Background:
- Childhood obesity is linked to inflammation and metabolic dysfunction.
- Camp-based interventions offer a unique setting for lifestyle modification in children.
- Understanding the impact of multi-component interventions on inflammatory markers and adipokines is crucial.
Purpose of the Study:
- To evaluate the effects of a 6-week camp-based intervention on inflammatory markers and adipokines in children.
- To assess the short-term (6 weeks) and long-term (52 weeks) impacts of the intervention.
- To explore potential mediators, such as body fat mass, of intervention effects.
Main Methods:
- 115 children were randomized into a day camp intervention arm (DCIA) or a standard intervention arm (SIA).
- The DCIA involved a 6-week camp and a 46-week family-based program; the SIA included weekly physical activity and an educational meeting.
- Serum levels of C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP1), leptin, and adiponectin were measured at baseline, 6 weeks, and 52 weeks.
Main Results:
- The DCIA showed significantly greater reductions in CRP and leptin at 6 weeks compared to the SIA.
- Changes in body fat mass mediated the intervention's effect on leptin.
- No significant intervention effects on CRP or leptin were observed at 52 weeks.
- No differences in MCP1 or adiponectin were found between groups at either time point.
Conclusions:
- A 6-week camp intervention can acutely reduce CRP and leptin levels in children.
- The observed reductions in CRP and leptin did not persist at the 52-week follow-up.
- The intervention's impact on leptin was linked to reductions in body fat mass.
Objective:
To examine the effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children.
Methods:
One hundred and fifteen children were recruited in Odense, Denmark (2012-2014). The participants were randomly allocated to either the day camp intervention arm (DCIA) or the standard intervention arm (SIA). The intervention for the DCIA consisted of a 6-week camp-based intervention and a 46-week family-based intervention. The SIA was offered one weekly physical activity session for 6 weeks and one educational meeting. C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP1), leptin, and adiponectin were measured in serum at baseline, 6 weeks and 52 weeks.
Results:
In comparison with the SIA, the reductions in CRP (P=0.003) and leptin (p<0.001) were larger in the DCIA at 6 weeks. The intervention effects on leptin were significantly mediated by the changes in body fat mass. No intervention effects on CRP and leptin were seen at 52 weeks. No between-group differences in changes in MCP1 and adiponectin were observed at 6 weeks or 52 weeks.
Conclusions:
The 6-week camp intervention resulted in reductions in CRP and leptin. The intervention effects did not persist to 52 weeks. The intervention effect on leptin was explained by changes in body fat mass.
