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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Generalized linear IgA dermatosis with palmar involvement.

Ivy N Norris, M Tye Haeberle1, Jeffrey P Callen

  • 1University of Louisville School of Medicine. mthaeb01@louisville.edu.

Dermatology Online Journal
|October 6, 2015
PubMed
Summary
This summary is machine-generated.

Linear IgA bullous dermatosis (LABD) is a rare blistering skin disease. Prominent hand involvement can be a key diagnostic clue for clinicians.

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Area of Science:

  • Dermatology
  • Immunofluorescence Microscopy

Background:

  • Linear IgA bullous dermatosis (LABD) is a subepidermal blistering disorder.
  • Diagnosis relies on clinicopathologic correlation and immunofluorescence confirmation of IgA deposition along the basement membrane zone (BMZ).

Observation:

  • This report highlights three cases of LABD with significant palmar involvement.
  • Palmar presentation can be a crucial physical exam finding.

Findings:

  • LABD diagnosis requires differentiating it from other bullous dermatoses due to differing treatment strategies.
  • Immunofluorescence microscopy is essential for confirming IgA deposition at the BMZ.

Implications:

  • Recognizing palmar involvement in LABD can lead to earlier diagnosis.
  • Prompt and appropriate therapy initiation significantly impacts patient outcomes.