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Updated: Apr 1, 2026

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[Noma/Cancrum oris: a neglected disease].

Maria García-Moro1, Enrique García-Merino, Angel Martín-Del-Rey

  • 1María García Moro, Facultad de Farmacia, Universidad de Salamanca, Spain. mgarciam@usal.es.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|October 7, 2015
PubMed
Summary

Noma is a severe orofacial disease primarily affecting children in impoverished regions, particularly Africa. This polymicrobial infection leads to rapid tissue destruction and is often fatal without prompt treatment.

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Area of Science:

  • Oral pathology
  • Infectious diseases
  • Public health

Context:

  • Noma, an aggressive gangrenous disease, devastates oral and facial tissues.
  • Historically global, it now predominantly affects children in disadvantaged areas, especially in Africa.
  • Associated factors include malnutrition, immunosuppression, and intraoral infections.

Purpose:

  • To consolidate existing information on Noma disease.
  • To enhance global understanding and awareness of this neglected pathology.

Summary:

  • Noma is a polymicrobial infection causing rapid necrosis of oral and facial tissues.
  • Key implicated microorganisms include Fusobacterium, Prevotella, Bacteroides, and Bacillus species.
  • High mortality and severe sequelae characterize untreated Noma.

Impact:

  • Aims to improve knowledge and awareness of Noma disease.
  • Highlights the need for intervention in affected populations.
  • Addresses the severe health and social consequences for survivors.