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Updated: Apr 1, 2026

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
Published on: April 17, 2017
Lipid droplets and associated proteins in the skin: basic research and clinical perspectives
Marlon R Schneider1, Shasha Zhang2, Peng Li3
1Gene Center, Institute of Molecular Animal Breeding and Biotechnology, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany. marlon.schneider@lmu.de.
Abstract:
Lipid droplets (LDs), the major organelles handling fat storage, comprise a hydrophobic neutral lipid core surrounded by a phospholipid monolayer embedded with a protein miscellany. Although lipids of the stratum corneum are essential for the skin barrier, and progressive lipid accumulation culminating in cell disruption is the hallmark of sebaceous differentiation, only a few studies touched on skin LD and associated proteins so far. Here, after briefly introducing the basic facts about LD and associated proteins, we discuss how forthcoming studies may unveil novel players in skin lipid metabolism and candidate target proteins for treating skin diseases.
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