Recent research progress with phospholipase C from Bacillus cereus
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Updated: Apr 1, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
Yan Lyu1, Lidan Ye2,3, Jun Xu4
1Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, No. 38 Zheda Road, Hangzhou, 310027, People's Republic of China. 21228185@zju.edu.cn.
Abstract:
Phospholipase C (PLC) catalyzes the hydrolysis of phospholipids to produce phosphate monoesters and diacylglycerol. It has many applications in the enzymatic degumming of plant oils. PLC Bc , a bacterial PLC from Bacillus cereus, is an optimal choice for this activity in terms of its wide substrate spectrum, high activity, and approved safety. Unfortunately, its large-scale production and reliable high-throughput screening of PLC Bc remain challenging. Herein, we summarize the research progress regarding PLC Bc with emphasis on the screening methods, expression systems, catalytic mechanisms and inhibitor of PLC Bc . This review hopefully will inspire new achievements in related areas, to promote the sustainable development of PLC Bc and its application.
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