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Related Concept Videos

Imaging Studies II: Ultrasonography01:24

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IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Related Experiment Video

Updated: Apr 1, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
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[Optoacoustic imaging].

M Fournelle1, S Tretbar2

  • 1Fraunhofer Institut für Biomedizinische Technik IBMT, Ensheimer Str. 48, 66386, St. Ingbert, Deutschland. marc.fournelle@ibmt.fraunhofer.de.

Der Radiologe
|October 7, 2015
PubMed
Summary

Optoacoustic imaging offers high contrast and resolution for medical diagnostics, overcoming ultrasound limitations for molecular imaging. This technique is nearing clinical application for early disease detection, including breast cancer and arthritis.

Keywords:
Contrast agentsFunctional imagingIn vivo imagingMolecular imagingVascularization

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Area of Science:

  • Medical imaging
  • Biomedical optics
  • Acoustic imaging

Context:

  • Ultrasound (US) is widely used but has poor soft tissue contrast and limitations for molecular imaging (MI).
  • Existing ultrasound-based MI is restricted to the vasculature due to contrast agent size limitations.

Purpose:

  • To introduce optoacoustic imaging as a novel modality combining optical contrast with acoustic resolution.
  • To highlight its potential for enhanced molecular imaging and overcoming conventional ultrasound limitations.

Summary:

  • Optoacoustic imaging generates signals based on local optical absorption and detects them acoustically, offering high contrast and resolution.
  • The technique is scalable for various applications, from microscopy to clinical imaging, with penetration depths of several centimeters.
  • Preclinical evaluations show optoacoustic techniques are highly suitable for MI, with ongoing clinical translation.

Impact:

  • Optoacoustic imaging promises improved early diagnosis of conditions like breast cancer and arthritis.
  • The technology is being investigated for applications in skin imaging.
  • This modality offers a pathway to advanced molecular imaging beyond the vascular network.