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Published on: February 15, 2014
Deep brain stimulation of the subthalamic nucleus: histological verification and 9.4-T MRI correlation
Othman Al-Helli1, David L Thomas2, Luke Massey3,4
1Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, London, WC1n 3BG, UK. othmanalhelli@gmail.com.
Background:
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using an MRI-guided and MRI-verified technique without microelectrode recording is an effective and safe surgical treatment for patients with Parkinson's disease (PD).
Objectives:
To assess the anatomical accuracy of lead placement after MRI-guided, MRI-verified STN DBS using post-mortem histology and high-field MRI at 9.4 T.
Methods:
We conducted post-mortem analysis of a patient's brain who had had MRI-guided, MRI-verified STN DBS for PD, using 9.4-T MRI and histology. After death, the brain was retrieved and a block including the electrode tracks down to the mesencephalon was examined with high-field MRI at 9.4 T and histological analysis.
Results:
High-field MRI images and corresponding histological examination showed that each electrode track ended within the intended target area, and that DBS did not cause significant neuroparenchymal tissue damage.
Conclusions:
This study supports the anatomical accuracy of the MRI-guided and MRI-verified method of STN DBS.
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