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Updated: Apr 1, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Multiple sclerosis: relapses, resource use, and costs.

A J Hawton¹, C Green²

¹Health Economics Group, University of Exeter Medical School, University of Exeter, South Cloisters, St Luke's Campus, Magdalen Road, Exeter, Devon, EX1 2LU, UK. a.hawton@exeter.ac.uk.

The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care

|October 7, 2015

Summary

This summary is machine-generated.

Multiple sclerosis (MS) relapses significantly increase healthcare costs, varying with relapse frequency, severity, and duration. Understanding these costs is crucial for effective treatment decisions and healthcare funding for MS patients.

Keywords:

Cost-effectiveness Costs Decision-making Multiple sclerosis Relapse Resource use

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Area of Science:

Neurology
Health Economics
Public Health

Background:

Relapses in multiple sclerosis (MS) significantly impact patients' lives but have been understudied regarding healthcare costs.
Limited understanding of relapse-related costs hinders cost-effectiveness analyses and healthcare funding decisions for MS treatments.

Purpose of the Study:

To quantify health and social care resource utilization and associated costs based on the frequency, severity, and duration of MS relapses.
To provide data for informed decision-making in MS healthcare provision and treatment evaluation.

Main Methods:

Utilized prospective, longitudinal data from the UK South West Impact of Multiple Sclerosis (MS) cohort.
Analyzed 11,800 questionnaires from 1441 individuals with MS, detailing relapse information and healthcare resource use.

Main Results:

The mean 6-monthly healthcare cost for individuals experiencing an MS relapse was £519, compared to £229 for those without a relapse.
Costs varied significantly based on relapse characteristics: untreated relapses cost £381, while hospitalizations due to relapses incurred a mean cost of £3579.
Resource use and costs were directly correlated with relapse frequency, severity, and duration.

Conclusions:

MS relapses represent a substantial and variable cost to health and social care systems.
The findings underscore the importance of considering relapse characteristics in cost-effectiveness analyses for MS treatments.
This data can guide healthcare policy and resource allocation for managing multiple sclerosis.