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T-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition

Roch Houot1, Liora Michal Schultz2, Aurélien Marabelle3

  • 1CHU Rennes, Service Hématologie Clinique, Rennes, France. INSERM U917, Rennes, France.

Cancer Immunology Research
|October 7, 2015
PubMed

Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their applications, present and future, into perspective.

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