Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebral circulation under normal and pathologic conditions.

O B Paulson1, G Waldemar, J F Schmidt

  • 1Department of Neurology, Rigshospitalet, Copenhagen, Denmark.

The American Journal of Cardiology
|February 2, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to 'Response to letter to the editor (JOTNS-D-25-02717 by Dr. Nie Lei)' [The Journal of the Neurological Sciences 2025 Volume 479 123752].

Journal of the neurological sciences·2025
Same author

Response to letter to the editor (JOTNS-D-25-02717 by Dr. Nie Lei).

Journal of the neurological sciences·2025
Same author

Serum neurofilament light chain levels are associated with cognitive decline in a consecutive cohort of patients with Alzheimer's disease.

Journal of the neurological sciences·2025
Same author

The association between migraine and dementia - a national register-based matched cohort study.

Public health·2022
Same author

Electroencephalographic functional connectivity is altered in persons with Down syndrome and Alzheimer's disease.

Journal of intellectual disability research : JIDR·2020
Same author

Increased short- and long-term mortality following infections in dementia: a nationwide registry-based cohort study.

European journal of neurology·2020
Same journal

Real-World Effectiveness and Tolerability of Sacubitril/Valsartan in Octogenarian Patients With Heart Failure: Results From the PARACHUTER Study.

The American journal of cardiology·2026
Same journal

ECG-Guided Conduction Pathways as a Lever to Shorten Post-TAVI Hospitalization.

The American journal of cardiology·2026
Same journal

Cystatin-C versus creatinine and kidney function in heart failure with preserved ejection fraction: a SOGALDI-PEF analysis.

The American journal of cardiology·2026
Same journal

Balloon-expandable versus Self-expanding Valves in Patients with Small Aortic Annuli Undergoing Transcatheter Aortic Valve Replacement.

The American journal of cardiology·2026
Same journal

Drug-Coated Balloons versus Drug-Eluting Stents following Coronary Atherectomy in Severely Calcified Lesions: A Systematic Review and Meta-Analysis.

The American journal of cardiology·2026
Same journal

Prehospital Statin Therapy and Outcomes in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

The American journal of cardiology·2026
See all related articles

Cerebral blood flow autoregulation maintains constant brain blood supply across arterial pressure changes. Chronic hypertension shifts this regulation, impairing tolerance to drops but improving tolerance to surges in blood pressure.

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Cerebrovascular Regulation

Background:

  • Autoregulation of cerebral circulation is crucial for maintaining constant cerebral blood flow (CBF) despite wide variations in arterial pressure.
  • Key limits for autoregulation are typically 60 mm Hg (lower) and 150 mm Hg (upper) mean arterial pressure.

Purpose of the Study:

  • To discuss the mechanisms of cerebral blood flow autoregulation.
  • To explore how sympathetic nervous system and renin-angiotensin system modulate this regulation.
  • To examine the impact of chronic hypertension on cerebral autoregulation limits and implications for treatment.

Main Methods:

  • Discussion of myogenic response and metabolic regulation as primary autoregulation mechanisms.
  • Analysis of neurohormonal modulation (sympathetic nervous system, renin-angiotensin system).

Related Experiment Videos

  • Review of structural and functional changes in cerebral resistance vessels in hypertension.

    • Main Results:

    • Chronic hypertension shifts the autoregulatory curve to higher arterial pressures.
    • This shift impairs tolerance to acute decreases in arterial pressure.
    • Tolerance to acute increases in arterial pressure is concurrently improved in hypertensive states.

    Conclusions:

    • Adaptive changes in cerebral resistance vessels underlie the hypertension-induced shift in autoregulation.
    • These adaptations are partially reversible with antihypertensive treatment.
    • Understanding autoregulation pathophysiology is vital before acute blood pressure-lowering interventions.