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Evaluation of cytotoxicity of some common ophthalmic drugs

M Li1, X-M Chen, J-J Liu

  • 1Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

European Review for Medical and Pharmacological Sciences
|October 7, 2015
PubMed

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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