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Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

Ilhem Messaoudi1, Gaya K Amarasinghe2, Christopher F Basler3

  • 1School of Medicine, University of California Riverside, Riverside, California 92521, USA.

Nature Reviews. Microbiology
|October 7, 2015
PubMed

Insights

Filoviruses like Ebola and Marburg suppress the host

Area of Science:

  • Virology
  • Immunology

Background:

  • Filoviruses, including Ebola and Marburg viruses, are zoonotic pathogens causing severe human disease.
  • Filovirus infections are marked by uncontrolled viral replication and host responses contributing to pathogenesis.

Purpose of the Study:

  • To describe mechanisms filoviruses use to evade host innate immunity.
  • To discuss the link between immune evasion and filovirus pathogenesis.

Main Methods:

  • Review of scientific literature on filovirus immune evasion.
  • Analysis of viral protein functions in blocking host antiviral responses.

Main Results:

  • Filoviruses potently suppress host innate antiviral responses, especially type I interferon.
  • Viral proteins are key to suppressing immune responses, enabling high viral replication.

Conclusions:

  • Understanding filovirus immune evasion mechanisms is crucial for understanding pathogenesis.
  • Targeting these evasion strategies may offer therapeutic avenues.

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