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Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

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Updated: Apr 1, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Microneedles for Transdermal Biosensing: Current Picture and Future Direction.

Letizia Ventrelli¹, Lucanos Marsilio Strambini¹, Giuseppe Barillaro^1,2

¹Dipartimento di Ingegneria dell'Informazione, Università di Pisa, Via G. Caruso 16, 56122, Pisa, Italy.

Advanced Healthcare Materials

|October 7, 2015

Summary

Microneedles are revolutionizing transdermal biosensing for point-of-care diagnostics. This technology enables minimally invasive, pain-free collection of clinical analytes, improving accessibility and reducing sample issues.

Keywords:

biomarkers biosensors glucose microneedles skin transdermal biosensing tumors

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Area of Science:

Biomedical Engineering
Biosensor Technology
Nanotechnology

Background:

Microneedles, miniaturized needles (hundreds of micrometers), are emerging for transdermal biosensing.
They offer minimally invasive, pain-free, and easy-to-use point-of-care (POC) applications.
Microneedles facilitate in situ biological sample collection for biochips.

Purpose of the Study:

To critically analyze the state-of-the-art in microneedle-based transdermal biosensing.
To bridge the gap between microneedle technology and biosensor development.
To highlight the potential of microneedles for real-world biosensing applications.

Main Methods:

Review of current microneedle designs and fabrication techniques for biosensing.
Analysis of microneedle-based biosensor performance for various clinical analytes.
Exploration of integration strategies for microneedles with biochip platforms.

Main Results:

Microneedles enable direct, in situ sample collection, minimizing invasiveness and contamination.
Transdermal biosensing with microneedles offers advantages over traditional blood extraction.
Development of user-friendly POC microdevices with potential for global accessibility.

Conclusions:

Microneedle technology presents a significant advancement for transdermal biosensing and biochip integration.
This approach promises to overcome limitations of conventional methods, enhancing diagnostics.
Future developments focus on optimizing microneedle-biosensor interfaces for broader clinical utility.