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High-Speed Intrinsic Dissolution Rate in One Minute Using the Single-Particle Intrinsic Dissolution Rate Method
Sami Svanbäck1, Henrik Ehlers1, Osmo Antikainen1
1Division of Pharmaceutical Chemistry and Technology, University of Helsinki , P.O. Box 56, FI-00014 Helsinki, Finland.
Analytical Chemistry
|October 7, 2015
Summary
A new optofluidic method measures intrinsic dissolution rate (IDR) in real-time from single microparticles. This single-particle intrinsic dissolution rate (SIDR) technique offers faster, more accurate solubility data for drug discovery.
Area of Science:
- Analytical Chemistry
- Physical Chemistry
- Materials Science
Background:
- Traditional intrinsic dissolution rate (IDR) measurements require a constant surface area.
- Existing high-throughput solubility methods can be resource-intensive.
Purpose of the Study:
- To develop a novel optofluidic method for real-time IDR determination from individual microparticles.
- To enable accurate solubility assessment using continuously changing surface areas.
Main Methods:
- Introduced an optofluidic single-particle intrinsic dissolution rate (SIDR) method.
- Utilized noninvasive optical monitoring and 3D particle morphology characterization.
- Analyzed dissolution from microparticles (14-747 μg) with changing effective surface areas.
Main Results:
- Achieved real-time IDR determination from individual microparticles.
- Obtained IDRs with an average relative standard deviation of 9.4%.
- Demonstrated a strong linear correlation (R(2) = 0.999) between SIDR and equilibrium solubility.
Conclusions:
- The SIDR method provides rapid (1 min) and accurate kinetic solubility data.
- This miniaturized approach can enhance drug discovery by replacing current methods.
- Offers resource-sparing, high-quality data acquisition for solubility determination.
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