Related Experiment Video

Updated: Apr 1, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

6.0K

Monocyte/HDL-cholesterol ratio predicts the definite stent thrombosis after primary percutaneous coronary

Elif Hande Ozcan Cetin1, Mehmet Serkan Cetin1, Uğur Canpolat1

  • 1Türkiye Yuksek Ihtisas Education & Research Hospital, Cardiology Department, Ankara, Turkey.

Biomarkers in Medicine
|October 7, 2015
PubMed

Insights

The monocyte to HDL ratio (M/H ratio) can predict stent thrombosis (ST) in ST-elevation myocardial infarction (STEMI) patients. A higher M/H ratio indicates an increased risk of ST following percutaneous coronary intervention.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • ST-elevation myocardial infarction (STEMI) is a critical cardiovascular event.
  • Stent thrombosis (ST) is a serious complication following percutaneous coronary intervention (PCI).
  • Identifying reliable predictors of ST is crucial for patient management.

Purpose of the Study:

  • To evaluate the predictive value of the monocyte count to HDL ratio (M/H ratio) for stent thrombosis (ST).
  • To assess the M/H ratio as a potential novel inflammatory marker in STEMI patients.

Main Methods:

  • A cohort of 1170 STEMI patients undergoing primary PCI was followed.
  • Median follow-up duration was 37.2 months.
  • Monocyte count to HDL ratio (M/H ratio) was analyzed in relation to ST occurrence.

Main Results:

  • 112 patients were diagnosed with definite ST during follow-up.
  • ST incidence was significantly higher in the highest M/H ratio tertile.
  • Cox regression analysis revealed a 2.2-fold increased risk of ST for the highest M/H ratio tertile, independent of other factors.

Conclusions:

  • The M/H ratio emerged as a novel marker of inflammation.
  • The M/H ratio is an independent predictor of ST in STEMI patients.
  • This finding may aid in risk stratification and personalized treatment strategies.
Abstract

Keywords:
PCIST elevation myocardial infarctioninflammationmonocyte to HDL ratiostent thrombosis

More Related Videos

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.8K
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

9.8K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
451
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.7K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
857
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
843