Jove
Visualize
Contact Us

Related Concept Videos

Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

4.6K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
4.6K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

9.1K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
9.1K
Direct Motor Pathways01:11

Direct Motor Pathways

5.3K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.

eLife·2026
Same author

Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.

Nature communications·2026
Same author

LSD persistently disrupts affective pain processing.

bioRxiv : the preprint server for biology·2026
Same author

Cortical circuits for whisker sensory perception-From barrel columns to brain-wide interactions.

Current opinion in neurobiology·2026
Same author

Redefining borders in the sensorimotor cortex.

eLife·2026
Same author

Biologically informed cortical models predict optogenetic perturbations.

eLife·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 1, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

4.0K

Cell-Type-Specific Sensorimotor Processing in Striatal Projection Neurons during Goal-Directed Behavior.

Tanya Sippy1, Damien Lapray1, Sylvain Crochet1

  • 1Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.

Neuron
|October 7, 2015
PubMed
Summary
This summary is machine-generated.

Direct pathway striatonigral neurons in the mouse striatum signal "go" for action initiation. These neurons are crucial for reward-based learning and goal-directed sensorimotor transformation.

More Related Videos

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

8.8K
Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
05:05

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Published on: December 2, 2022

2.1K

Related Experiment Videos

Last Updated: Apr 1, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

4.0K
Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

8.8K
Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
05:05

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Published on: December 2, 2022

2.1K

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience

Background:

  • The striatum is vital for reward-based learning and action selection.
  • It integrates sensorimotor and reward signals.

Purpose of the Study:

  • To investigate the role of striatal projection neuron pathways in goal-directed sensorimotor transformation.
  • To determine the specific contribution of direct and indirect pathways to action initiation.

Main Methods:

  • Whole-cell membrane potential recordings in the dorsolateral striatum of mice.
  • Behavioral task involving whisker deflection and reward.
  • Optogenetic stimulation of striatal projection neuron pathways.

Main Results:

  • Striatal projection neurons showed task-related modulation, firing more on successful trials.
  • Direct pathway neurons, but not indirect pathway neurons, responded early to sensory input.
  • Optogenetic activation of direct pathway neurons mimicked sensory stimulation, eliciting licking.

Conclusions:

  • Direct pathway striatonigral neurons provide a critical "go" signal for sensorimotor transformation.
  • These neurons are essential for initiating goal-directed actions based on sensory cues and rewards.