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Histoacryl. Its use in aesthetic facial plastic surgery
1Department of Head and Neck Surgery, UCLA Medical School.
Archives of Otolaryngology--Head & Neck Surgery
|February 1, 1989
Summary
Butyl-2-cyanoacrylate (Histoacryl) is a safe and effective tissue adhesive, showing minimal adverse effects in a clinical trial. This cyanoacrylate offers advantages over traditional sutures for wound healing.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Medical Adhesives
Background:
- Cyanoacrylates, discovered in 1949, have been explored as potential ideal tissue adhesives.
- Development of various cyanoacrylate forms aimed to mitigate tissue toxicity.
- Butyl-2-cyanoacrylate (Histoacryl) exhibits low tissue reactivity and toxicity.
Purpose of the Study:
- To review the historical development of tissue adhesives.
- To discuss technical considerations for using cyanoacrylate tissue adhesives.
- To evaluate the safety and efficacy of butyl-2-cyanoacrylate (Histoacryl) in surgical wound closure.
Main Methods:
- Historical literature review of tissue adhesives.
- Discussion of technical aspects of cyanoacrylate application.
- Clinical trial involving 100 patients treated with Histoacryl on surgical wounds.
Main Results:
- Butyl-2-cyanoacrylate (Histoacryl) demonstrated low tissue reactivity and toxicity.
- Extensive use in middle ear surgery showed minimal adverse effects.
- A six-month follow-up of 100 patients revealed no significant adverse effects on wound healing, graft rejection, or infection.
Conclusions:
- Butyl-2-cyanoacrylate (Histoacryl) represents a promising tissue adhesive with low adverse effects.
- Histoacryl offers numerous advantages compared to conventional suture techniques.
- The compound is suitable for various surgical wound applications, including middle ear surgery.