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Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
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Nickel Allergy Is a Risk Factor for Endometriosis: An 11-Year Population-Based Nested Case-Control Study
Jin-Sung Yuk1, Jong Seung Shin2, Ji-Yeon Shin3
1Department of Obstetrics and Gynecology, School of Medicine, Eulji University, Daejeon, South Korea; Department of Obstetrics and Gynecology, MizMedi Hospital, Seoul, South Korea.
Plos One
|October 7, 2015
Summary
Nickel allergy is a significant risk factor for endometriosis. This study found a higher prevalence of nickel allergy in women with endometriosis, suggesting a potential link.
Area of Science:
- Gynecology
- Immunology
- Epidemiology
Background:
- Previous cross-sectional studies suggest an association between nickel allergy and endometriosis.
- Causal evidence linking nickel allergy and endometriosis remains limited.
Purpose of the Study:
- To investigate the prevalence of nickel allergy in women diagnosed with endometriosis compared to those without.
- To determine if nickel allergy is a risk factor for developing endometriosis.
Main Methods:
- Utilized a South Korean National Health Insurance Service (NHIS) sample cohort (approx. 1 million individuals, 2002-2013).
- Identified endometriosis cases (N80.X codes, surgery, drugs) from 2009-2013.
- Defined nickel allergy by simultaneous diagnosis (L23.0) and patch test codes (2002-2008).
- Matched 997 endometriosis patients with 3,988 controls (4:1 ratio) by age and socioeconomic status.
Main Results:
- Nickel allergy was present in 0.8% of the endometriosis group (8/997) and 0.3% of the control group (13/3,988).
- Adjusted analysis revealed a significantly higher rate of nickel allergy in women with endometriosis (OR: 2.474, 95% CI: 1.023–5.988, p=0.044).
Conclusions:
- Nickel allergy is identified as a potential risk factor for endometriosis.
- The findings support a link between nickel allergy and the development of endometriosis.
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