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Updated: Apr 1, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis
Adeline S L Ng1, Joel Kramer1, Alejandro Centurion2
1Memory and Aging Center, University of California, San Francisco, Sandler Neurosciences Centre, 675 Nelson Rising Lane, Suite 190, San Francisco, CA 94158, USA.
Abstract:
Autoantibodies associated with autoimmune limbic encephalitis (ALE) have been well-characterized, with intracellular neuronal antibodies being less responsive to immunotherapy than antibodies to cell surface antigens. Adenylate kinase 5 (AK5) is a nucleoside monophosphate kinase vital for neuronal-specific metabolism and is located intracellularly in the cytosol and expressed exclusively in the brain. Antibodies to AK5 had been previously identified but were not known to be associated with human disease prior to the report of two patients with AK5-related ALE (Tuzun et al., 2007). We present the complete clinical picture for one of these patients and the first reported neuropathology for AK5 ALE.
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