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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency and Niche of Bulge Stem Cell01:06

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Related Experiment Video

Updated: Apr 1, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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WOX5 is Shining in the Root Stem Cell Niche.

Xiangpei Kong1, Songchong Lu1, Huiyu Tian1

  • 1The Key Laboratory of Plant Cell Engineering and Germplasm Innovation, Ministry of Education, College of Life Sciences, Shandong University, 27 Shanda South Road, Jinan, Shandong, 250100, China.

Trends in Plant Science
|October 7, 2015
PubMed
Summary

The WUS-RELATED HOMEOBOX 5 (WOX5) gene maintains root stem cell identity. Recent studies reveal how WOX5 is regulated and its crucial role in stem cell niche maintenance.

Keywords:
quiescent centerroot apical meristemstem cell homeostasis

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Area of Science:

  • Plant developmental biology
  • Stem cell biology
  • Molecular genetics

Background:

  • The quiescent center (QC) is essential for root stem cell niche maintenance.
  • The WUSCHEL-RELATED HOMEOBOX 5 (WOX5) gene is a key regulator of stem cell identity in plants.
  • Understanding the regulation of WOX5 is critical for comprehending root development.

Purpose of the Study:

  • To elucidate the regulatory mechanisms controlling WOX5 expression.
  • To highlight the role of WOX5 in maintaining the root stem cell niche.
  • To integrate recent findings on WOX5 function in root development.

Main Methods:

  • Gene expression analysis
  • Molecular genetics techniques
  • Bioinformatic approaches

Main Results:

  • WOX5 expression is tightly regulated within the quiescent center.
  • WOX5 directly influences columella stem cell (CSC) identity.
  • Disruptions in WOX5 regulation lead to defects in stem cell niche maintenance.

Conclusions:

  • WOX5 is a pivotal factor in preserving the root stem cell niche.
  • Recent research provides a comprehensive view of WOX5 regulation and function.
  • Further studies on WOX5 will advance our understanding of plant stem cell biology.