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Updated: Apr 1, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii
Henrik Harms1, Stefan Kehraus1, Damun Nesaei-Mosaferan1
1Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
Abstract:
The ascomycete Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. Three new steroids (1-3), two of which are present as glycosides, with an untypical pattern of carbon-carbon double bounds, were obtained from fungal extracts, as well as the known xanthocillin X dimethyl ether (4). Compounds 2 and 4 were evaluated in an Alzheimer's disease cellular assay and found capable of preventing the enhanced production of amyloid β-42 in Aftin-5 treated cells. Aβ-42 lowering agents are considered as candidates for the treatment of neurodegenerative Alzheimer's disease.
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