Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Evolving Landscape of Terahertz Biosensing: From Sensitivity to Precision.

ACS applied materials & interfaces·2026

Same author

Socioeconomic disparities in modifiable risk burden and dementia prevention: A prospective cohort study.

The journal of nutrition, health & aging·2026

Same author

Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.

Molecular psychiatry·2026

Same author

Engineering Apical Integrin-Binding Cellular Patches to Direct Cell Reprogramming via Mechanical Remodeling.

ACS nano·2026

Same author

Porous microneedle-based electrochemical aptamer biosensor for the collection and quantitative analysis of dry eye disease biomarkers.

Lab on a chip·2026

Same author

Rest-Activity Timing Phenotypes and Mental Health: A Longitudinal Analysis of 24-Hour Accelerometry in Population-Based Cohorts.

Health data science·2026

Same journal

Turbulent flow in a vortex separator with a directed pipe inlet.

Scientific reports·2026

Same journal

Systematic characteristic evaluation of clay-based cementitious material derived from calcium carbide residue and waste tile powder.

Scientific reports·2026

Same journal

Retraction Note: Improvement of a rapid diagnostic application of monoclonal antibodies against avian influenza H7 subtype virus using Europium nanoparticles.

Scientific reports·2026

Same journal

Applying large language models to spam detection in the Kazakh low-resource language setting.

Scientific reports·2026

Same journal

An open-source 3D printing system enabling in-situ freeze-thaw processing of hydrogels.

Scientific reports·2026

Same journal

An enhanced EfficientNet framework for automated waste classification using cosine annealing and label smoothing.

Scientific reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 1, 2026

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

A Nanoparticle-based Sensor Platform for Cell Tracking and Status/Function Assessment.

David Yeo¹, Christian Wiraja¹, Yon Jin Chuah¹

¹School of Chemical &Biomedical Engineering, Nanyang Technological University, Singapore.

Scientific Reports

|October 7, 2015

Summary

This summary is machine-generated.

This study introduces a novel nanosensor platform for real-time, noninvasive cell monitoring. These biodegradable nanosensors continuously track biomarkers, overcoming limitations of current nanoparticle tracking methods in cell therapy.

More Related Videos

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Harmonic Nanoparticles for Regenerative Research

Harmonic Nanoparticles for Regenerative Research

Published on: May 1, 2014

Related Experiment Videos

Last Updated: Apr 1, 2026

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Harmonic Nanoparticles for Regenerative Research

Harmonic Nanoparticles for Regenerative Research

Published on: May 1, 2014

Area of Science:

Biomedical Engineering
Nanotechnology
Cell Biology

Background:

Current nanoparticles for cell tracking in biomedical applications like cell therapy have limitations.
Existing methods often fail to provide real-time, noninvasive monitoring of cell status and functions.
False positive signals are a common issue with current nanoparticle tracking technologies.

Purpose of the Study:

To develop a nanosensor platform for real-time tracking of specific biomarkers.
To enable noninvasive monitoring of cell status and functions.
To overcome the limitations of existing nanoparticle-based cell tracking methods.

Main Methods:

Synthesized biodegradable polymeric nanoparticles encapsulating sensor molecules.
Nanosensors were designed for intracellular entry and sustained release of sensor molecules in the cytoplasm.
Developed a system where sensor molecules remain 'Off' in the absence of biomarkers and 'On' upon biomarker expression.

Main Results:

Demonstrated a nanosensor platform for continuous, real-time monitoring of intracellular events.
Successfully synthesized three nanosensor formulations for proof-of-concept studies.
Validated nanosensors for monitoring cell viability, nitric oxide secretion, and beta-actin mRNA expression.

Conclusions:

The developed nanosensor platform offers a promising solution for real-time, noninvasive cell monitoring.
This technology has significant potential for applications in cell therapy and biomedical research.
The nanosensor system provides a reliable method to track cellular functions by detecting specific biomarkers.