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Updated: Apr 1, 2026

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
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Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

D B Hancock1, G W Reginsson2, N C Gaddis3

  • 1Behavioral and Urban Health Program, Behavioral Health and Criminal Justice Research Division, Research Triangle Institute International, Research Triangle Park, NC, USA.

Translational Psychiatry
|October 7, 2015
PubMed
Summary

A genome-wide study found a CHRNA4 gene variant (rs2273500-C) linked to nicotine dependence severity. This variant affects CHRNA4 expression and increases lung cancer risk, primarily through smoking behavior.

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