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Thalamic neuron models encode stimulus information by burst-size modulation.

Daniel H Elijah1, Inés Samengo2, Marcelo A Montemurro1

  • 1Faculty of Life Sciences, The University of Manchester Manchester, UK.

Frontiers in Computational Neuroscience
|October 7, 2015
PubMed
Summary
This summary is machine-generated.

Thalamic neurons use a general n-spike burst code to encode sensory information. This burst code efficiently transmits data about complex input features, regardless of neuron model complexity.

Keywords:
burstinformation theorymultivariate analysisneural codereverse correlationsingle neuron modelspike-triggered averagethalamus

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Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Thalamic neurons traditionally fire in tonic mode during wakefulness and burst mode during sleep.
  • Emerging evidence indicates thalamic bursts may play a role in sensory information encoding.

Purpose of the Study:

  • To investigate the neural code underlying thalamic bursts.
  • To determine if the burst code is a general property or neuron-specific.
  • To compare information transmission in phenomenological versus biophysically detailed neuron models.

Main Methods:

  • Utilized reverse correlation and information theory to analyze input selectivity.
  • Employed two neuron models: a phenomenological model and a detailed biophysical model.
  • Assessed information transmission regarding classical and generalized input features.

Main Results:

  • Both models demonstrated that n-spike bursts encode information by modulating spike count in response to input features.
  • Bursts transmitted significantly more information (6x) about generalized input features compared to classical ones.
  • Optimal stimulus features were identified within a ~120 ms time window around burst onset.

Conclusions:

  • The neural code for thalamic bursts is largely consistent between simple and complex models.
  • A simple phenomenological model captures essential computational properties of the thalamic burst code.
  • The n-spike burst code appears to be a general characteristic of thalamic neurons for sensory encoding.