Related Experiment Video
Updated: Apr 1, 2026

Measuring Skeletal Muscle Thermogenesis in Mice and Rats
Published on: July 27, 2022
Metabolic Effects of FGF-21: Thermoregulation and Beyond
Bin Ni1, Jared S Farrar1, Janina A Vaitkus1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Virginia Commonwealth University School of Medicine , Richmond, VA , USA.
Abstract:
Fibroblast growth factor (FGF)-21, a member of the FGF family, is a novel hormone involved in the control of metabolism by modulating glucose homeostasis, insulin sensitivity, ketogenesis, and promoting adipose tissue "browning." Recent studies demonstrated that brown adipose tissue is not only a target for FGF-21, but is also a potentially important source of systemic FGF-21. These findings support the hypothesis that FGF-21 plays a physiologic role in thermogenesis and thermogenic recruitment of white adipose tissue by an autocrine-paracrine axis. This review examines the role of FGF-21 in thermogenesis from the perspective of cell-based, animal model, and human studies. We also present recent advances in the characterization of FGF-21's regulation of metabolism.
More Related Videos
04:54Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
Published on: June 2, 2023
08:06Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Related Concept Videos
Thermoregulation
Body Temperature
Body Temperature
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
Factors Affecting Body Temperature
Factors may include:
Effects of Temperature on Free Energy
Decreased Body Temperature