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Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation

Kailin Lin1, Song Chen2, Gang Chen2

  • 1Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology , Wuhan , China.

Frontiers in Immunology
|October 7, 2015
PubMed

Memory T cells are necessary for protective immunity against invading pathogens, especially under conditions of immunosuppression. However, their presence also threatens transplant survival, making transplantation a great challenge. Significant progress has been achieved in recent years in advancing our understanding of the role that memory T cells play in transplantation. This review focuses on the latest advances in our understanding of the involvement of memory T cells in graft rejection and transplant tolerance and discusses potential strategies for targeting memory T cells in order to minimize allograft rejection and optimize clinical outcomes.

Keywords:
allograft rejectionmemory T cellstherapytolerancetransplantation

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