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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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Induction and Validation of Cellular Senescence in Primary Human Cells
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Senescence: Is It Universal or Not?

Sergi Munné-Bosch1

  • 1Departament de Biologia Vegetal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain.

Trends in Plant Science
|October 8, 2015
PubMed
Summary

Perennial plants and some animals with continuous growth may avoid aging. This review explores how ongoing growth in plants might prevent senescence, questioning if aging is universal.

Area of Science:

  • Plant biology
  • Gerontology
  • Evolutionary biology

Background:

  • Senescence, or aging, is observed in many organisms.
  • Indeterminate growers, like perennial plants, appear to escape aging.
  • Some plants exhibit negligible or negative senescence, improving with age.

Purpose of the Study:

  • To review recent findings on senescence in perennial plants.
  • To propose continuous growth as a mechanism preventing senescence.
  • To discuss the universality of senescence.

Main Methods:

  • Literature review of senescence studies in perennial plants.
  • Analysis of growth patterns and aging in indeterminate growers.
  • Synthesis of current research on plant aging.
Keywords:
Agingindeterminate growthperennial plantsrejuvenationsenescence

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Main Results:

  • Most angiosperms do not show signs of senescence.
  • Perennial plants in natural habitats can display negligible or negative senescence.
  • Continuous growth is proposed as a key factor in preventing plant senescence.

Conclusions:

  • Senescence may not be a universal biological process.
  • Continuous growth in perennial plants is linked to the absence of aging.
  • Further research is needed to understand the mechanisms preventing senescence in plants.