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Simulating photoacoustic waves produced by individual biological particles with spheroidal wave functions
Yong Li1,2, Hui Fang3, Changjun Min3
1Institute of Modern Optics, Key Laboratory of Optical Information Science and Technology, Ministry of Education of China, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300071, China.
Abstract:
Under the usual approximation of treating a biological particle as a spheroidal droplet, we consider the analysis of its size and shape with the high frequency photoacoustics and develop a numerical method which can simulate its characteristic photoacoustic waves. This numerical method is based on the calculation of spheroidal wave functions, and when comparing to the finite element model (FEM) calculation, can reveal more physical information and can provide results independently at each spatial points. As the demonstration, red blood cells (RBCs) and MCF7 cell nuclei are studied, and their photoacoustic responses including field distribution, spectral amplitude, and pulse forming are calculated. We expect that integrating this numerical method with the high frequency photoacoustic measurement will form a new modality being extra to the light scattering method, for fast assessing the morphology of a biological particle.
