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Interventions for hidradenitis suppurativa
John R Ingram1, Pick-Ngor Woo, Ser Ling Chua
1Department of Dermatology & Wound Healing, Cardiff Institute of Infection & Immunity, Cardiff University, 3rd Floor Glamorgan House, Heath Park, Cardiff, UK, CF14 4XN.
The Cochrane Database of Systematic Reviews
|October 8, 2015
Summary
This review found moderate evidence that adalimumab and infliximab improve quality of life for hidradenitis suppurativa (HS) patients. However, more research is needed to confirm efficacy and safety for HS treatments.
Area of Science:
- Dermatology
- Clinical Trials
- Evidence-Based Medicine
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition affecting approximately 1% of the population.
- HS is characterized by painful boils in flexural areas, typically starting in early adulthood.
Purpose of the Study:
- To systematically assess the effects of various interventions for hidradenitis suppurativa (HS) across all age groups.
- To evaluate the impact of treatments on quality of life and adverse effects.
Main Methods:
- Conducted a comprehensive literature search of multiple databases up to August 2015.
- Included randomized controlled trials (RCTs) of all interventions for HS.
- Two independent reviewers assessed study eligibility, quality, and extracted data on primary outcomes.
Main Results:
- Twelve RCTs with 615 participants were included, spanning 32 years.
- Adalimumab (40 mg weekly) showed moderate evidence of improving quality of life in moderate to severe HS.
- Infliximab also demonstrated improvement in quality of life, based on moderate quality evidence.
Conclusions:
- Significant gaps exist in the evidence base for HS treatments.
- Weekly adalimumab dosing shows potential but requires further safety evaluation; infliximab also shows promise.
- More high-quality RCTs are needed, especially for oral treatments and surgical procedures, with validated outcome measures.
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