Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemoglobin01:24

Hemoglobin

9.9K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
9.9K
Amino Acid Biosynthetic Pathways01:29

Amino Acid Biosynthetic Pathways

1.6K
Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
1.6K
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

6.0K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
6.0K
Biosynthesis in Bacteria01:24

Biosynthesis in Bacteria

964
Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
964
Biosynthesis of Lipids01:29

Biosynthesis of Lipids

873
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
873
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

11.5K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
11.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chloroplast signaling: retrograde regulation revelations.

Current biology : CBยท2011
Same author

Heme oxygenase 2 of the cyanobacterium Synechocystis sp. PCC 6803 is induced under a microaerobic atmosphere and is required for microaerobic growth at high light intensity.

Photosynthesis researchยท2009
Same author

Photosynthetic pigments: perplexing persistent prevalence of 'superfluous' pigment production.

Current biology : CBยท2008
Same author

Enzymes of the heme biosynthetic pathway in the nonphotosynthetic alga Polytomella sp.

Eukaryotic cellยท2005
Same author

Subcellular localization and light-regulated expression of protoporphyrinogen IX oxidase and ferrochelatase in Chlamydomonas reinhardtii.

Plant physiologyยท2005
Same author

Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor.

Acta crystallographica. Section D, Biological crystallographyยท2005

Related Experiment Video

Updated: Apr 1, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
09:43

Measurement of Heme Synthesis Levels in Mammalian Cells

Published on: July 9, 2015

12.6K

Biosynthesis of Hemes.

Samuel I Beale

    Ecosal Plus
    |October 8, 2015
    PubMed
    Summary

    This review details heme biosynthesis in E. coli and serovar Typhimurium, highlighting its common pathway with other organisms. Protoheme levels regulate heme synthesis, impacting essential cellular functions.

    Area of Science:

    • Biochemistry
    • Microbiology
    • Molecular Biology

    Background:

    • Heme biosynthesis is crucial for enzyme function in mineral nutrition, redox metabolism, and signal transduction.
    • Tetrapyrrole biosynthesis shares a common pathway, with insights gained from diverse organisms like plants and cyanobacteria.

    Purpose of the Study:

    • To review the structures and biosynthesis of hemes specifically in E. coli and serovar Typhimurium.
    • To discuss the broader applicability of tetrapyrrole biosynthesis knowledge across different life forms.

    Main Methods:

    • Review of existing literature on heme and tetrapyrrole biosynthesis.
    • Analysis of key enzymatic steps, including ALA condensation and protoporphyrin IX formation.

    Main Results:

    More Related Videos

    Developing Photosensitizer-Cobaloxime Hybrids for Solar-Driven H2 Production in Aqueous Aerobic Conditions
    10:21

    Developing Photosensitizer-Cobaloxime Hybrids for Solar-Driven H2 Production in Aqueous Aerobic Conditions

    Published on: October 5, 2019

    9.1K
    Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure
    06:39

    Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure

    Published on: August 28, 2009

    14.5K

    Related Experiment Videos

    Last Updated: Apr 1, 2026

    Measurement of Heme Synthesis Levels in Mammalian Cells
    09:43

    Measurement of Heme Synthesis Levels in Mammalian Cells

    Published on: July 9, 2015

    12.6K
    Developing Photosensitizer-Cobaloxime Hybrids for Solar-Driven H2 Production in Aqueous Aerobic Conditions
    10:21

    Developing Photosensitizer-Cobaloxime Hybrids for Solar-Driven H2 Production in Aqueous Aerobic Conditions

    Published on: October 5, 2019

    9.1K
    Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure
    06:39

    Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure

    Published on: August 28, 2009

    14.5K
    • The common pathway starts with 5-aminolevulinic acid (ALA) and includes key enzymes like Porphobilinogen synthase (PBGS) and Protoporphyrinogen IX oxidase (PPX).
    • Evidence supports a regulatory model where free protoheme controls the initial unique step in heme synthesis.

    Conclusions:

    • Heme biosynthesis regulation in E. coli and serovar Typhimurium is linked to cellular protoheme levels.
    • Understanding this pathway is vital for comprehending essential cellular processes and has implications across various organisms.