Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current and future trials with zidovudine.

J M Yeo1

  • 1Wellcome Research Laboratories, Beckenham, U.K.

The Journal of Infection
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Zidovudine (AZT) significantly improved survival in patients with advanced HIV/AIDS, leading to early trial termination. Ongoing studies explore its long-term effects and earlier use in HIV management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depolarization vs. repolarization: what is the mechanism of ventricular arrhythmogenesis underlying sodium channel haploinsufficiency in mouse hearts?

Acta physiologica (Oxford, England)·2016
Same author

Bare below the elbows: was the target the white coat?

The Journal of hospital infection·2015
Same author

Effects of Cordyceps militaris on the growth of rumen microorganisms and in vitro rumen fermentation with respect to methane emissions.

Journal of dairy science·2014
Same author

A curious case of unilateral spider nevi, cirrhosis and stroke: unilateral nevoid telangiectasia syndrome.

The journal of the Royal College of Physicians of Edinburgh·2013
Same author

Effect of feeding high-temperature, microtime-treated diets with different lipid sources on conjugated linoleic acid formation in finishing Hanwoo steers.

Journal of animal science·2008
Same author

Effects of dietary amino acid balance on the response of dairy cows to an increase of milking frequency from twice to three times daily.

Journal of dairy science·2003

Area of Science:

  • Virology
  • Immunology
  • Pharmacology

Background:

  • Zidovudine (AZT) was evaluated in a placebo-controlled trial for patients with Acquired Immune Deficiency Syndrome (AIDS) and severe AIDS-Related Complex (ARC).
  • The initial trial focused on patients with Pneumocystis carinii pneumonia and severe ARC.

Purpose of the Study:

  • To assess the long-term efficacy and tolerance of zidovudine in HIV/AIDS management.
  • To investigate strategies for improving zidovudine's therapeutic index.

Main Methods:

  • Initial placebo-controlled trial followed by an open-label extension study.
  • Monitoring of survival, side-effects (anemia, neutropenia), and dose modification strategies.
  • Ongoing trials evaluating zidovudine for Kaposi's sarcoma and earlier HIV infection stages.

Related Experiment Videos

Main Results:

  • Zidovudine demonstrated increased survival, prompting early termination of the initial trial.
  • Anemia and neutropenia were identified as predominant side-effects in advanced disease.
  • Research is expanding to include combination therapies and earlier intervention in HIV infection.

Conclusions:

  • Zidovudine offers survival benefits for advanced HIV/AIDS patients.
  • Strategies to mitigate side-effects and enhance efficacy are under investigation.
  • Further research is crucial to define zidovudine's role across the spectrum of HIV infection.