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Updated: Apr 1, 2026

Catheterization of Intestinal Loops in Ruminants
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Peste des petits ruminants.

S Parida1, M Muniraju2, M Mahapatra2

  • 1The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, United Kingdom; National Institute for Animal Biotechnology, Miyapur, Hyderabad, India.

Veterinary Microbiology
|October 8, 2015
PubMed
Summary
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Peste des petits ruminants virus (PPRV) poses a significant threat to small ruminant agriculture. Available vaccines are crucial for the global eradication goal, with DIVA strategies potentially accelerating surveillance efforts.

Area of Science:

  • Veterinary Virology
  • Infectious Diseases
  • Animal Agriculture

Background:

  • Peste des petits ruminants virus (PPRV) causes a highly contagious disease in small ruminants.
  • PPRV is endemic in Africa, the Middle East, and Asia, hindering sustainable agriculture.
  • The World Organisation for Animal Health (OIE) and FAO aim to eradicate PPRV by 2030.

Purpose of the Study:

  • To provide an overview of current knowledge on PPRV.
  • To discuss diagnostic tools and available vaccines.
  • To explore advancements in recombinant and multivalent vaccines for PPRV control.

Main Methods:

  • Literature review of PPRV origin, circulation, and evolution.
  • Analysis of current diagnostic techniques.
Keywords:
Control and eradicationCountry-wise virus circulationLive attenuated vaccineMolecular evolutionPPRPathogenesisPotential DIVA and multivalent vaccineReverse genetics

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  • Assessment of existing and emerging vaccine technologies.
  • Main Results:

    • Existing vaccines are available for PPRV control.
    • Novel DIVA (differentiating infected from vaccinated animals) vaccines can improve serological surveillance efficiency.
    • Recent developments include recombinant vaccines and potential for multivalent formulations.

    Conclusions:

    • PPRV remains a major impediment to small ruminant production globally.
    • Effective vaccines exist, but DIVA strategies are needed for efficient eradication campaigns.
    • Continued research into novel vaccine platforms is essential for global PPRV elimination.