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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Evaluation of antibacterial activity of caffeic acid encapsulated by β-cyclodextrins
Eva Pinho1,2, Graça Soares2, Mariana Henriques1
1a CEB, Centre for Biological Engineering, LIBRO - Laboratório De Investigacão Em Biofilmes Rosário Oliveira, University of Minho , Campus Gualtar , Braga , Portugal and.
Context:
Caffeic acid is described as antibacterial, but this bioactive molecule has some issues regarding solubility and stability to environmental stress. Thus, encapsulation devices are required.
Objective:
The aim of this work was to study the effect of the caffeic acid encapsulation by cyclodextrins on its antibacterial activity.
Materials And Methods:
The interactions between the caffeic acid and three cyclodextrins (β-cyclodextrin (βCD), 2-hydroxypropyl-β-cyclodextrin (HPβCD) and methyl-β-cyclodextrin were study.
Results And Discussion:
The formation of an aqueous soluble inclusion complex was confirmed for βCD and HPβCD with a 1:1 stoichiometry. The βCD/caffeic acid complex showed higher stability than HPβCD/caffeic acid. Caffeic acid antibacterial activity was similar at pH 3 and pH 5 against the three bacteria (K. pneumoniae, S. epidermidis and S. aureus).
Conclusions:
The antibacterial activity of the inclusion complexes was described here for the first time and it was shown that the caffeic acid activity was remarkably enhanced by the cyclodextrins encapsulation.
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