PIMASERTIB AND SEROUS RETINAL DETACHMENTS
Related Experiment Video
Updated: Aug 6, 2026
Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
Published on: September 11, 2013
Alaa AlAli1, Ahmad Bushehri, Jonathan C Park
1Departments of *Ophthalmology and Vision Sciences, and †Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
Purpose:
To report a case of multifocal serous retinal detachments associated with pimasertib.
Methods:
The authors report a 26-year-old patient who developed bilateral multifocal serous retinal detachments appearing 2 days after starting pimasertib (as part of a clinical trial investigating its use in low-grade metastatic ovarian cancer) and rapidly resolving 3 days after stopping it.
Conclusion:
The mechanism of MEK inhibitor induced visual toxicity remains unclear. The pathophysiology of multifocal serous retinal detachments as a complication of pimasertib is still poorly understood.
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