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Targretin Improves Cognitive and Biological Markers in a Patient with Alzheimer's Disease
Nathalie Pierrot1,2, Renaud Lhommel1,2,3, Lisa Quenon1,2
1Université catholique de Louvain, Brussels, Belgium.
Abstract:
We present the effects of Targretin® (bexarotene) on cognition and biomarkers in a patient with mild Alzheimer's disease (AD). Targretin® is a Retinoic X Receptor (RXR) agonist shown to improve synaptic and cognitive functions in animal models of AD by increasing neuronal cholesterol efflux. After 6 months of treatment with Targretin® 300 mg/day, memory improved by about 40% and the tau protein in the cerebrospinal fluid decreased by about 20% . No significant side effects were noticed. This observation in a single patient indicates that Targretin® may improve memory performance and biological markers at an early stage of AD.
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