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Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Building a DoD Biorepository for the Future: Potential Benefits and Way Forward.

Luther E Lindler¹

¹Armed Forces Health Surveillance Center, 11800 Tech Road, Silver Spring, MD 20904.

Military Medicine

|October 8, 2015

Summary

The Department of Defense (DoD) should enhance its biospecimen repository with nucleic acid sources. This upgrade will leverage advanced omics technologies for improved force health protection and environmental exposure tracking.

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Area of Science:

Molecular biology
Genomics
Proteomics
Metabolomics
Systems biology

Background:

The Department of Defense (DoD) requires methods to identify service members exposed to environmental hazards.
The existing DoD Serum Repository, established in 1987, aids in studying environmental exposures and is linked to health records.
Current limitations include the lack of a reliable nucleic acid source within the repository.

Purpose of the Study:

To highlight the need for an enhanced biospecimen repository within the DoD.
To discuss the application of omics technologies for medical practice and public health.
To support future force health protection initiatives.

Main Methods:

Review of omics technologies and their applications.
Analysis of the DoD Serum Repository's capabilities and limitations.
Discussion of requirements for an enhanced biospecimen repository.

Main Results:

Omics technologies offer advanced molecular analyses of human physiological states.
Existing DoD biorepository lacks nucleic acid, limiting modern molecular analyses.
An enhanced repository is crucial for leveraging omics for force health protection.

Conclusions:

The DoD should establish an enhanced biospecimen repository with nucleic acid.
This enhancement will enable the use of omics technologies for critical health assessments.
Future applications include personalized medicine and improved public health surveillance for military personnel.